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- Title
Role of Intracellular Ca<sup>2+</sup>, Reactive Oxygen Species, Mitochondria Transmembrane Potential, and Antioxidant Enzymes in Heavy Metal-Induced Apoptosis in Fish Cells.
- Authors
Xiang, L. X.; Shao, J. Z.
- Abstract
The article cites a study conducted to determine the role of intracellular calcium ion, reactive oxygen species, mitochondria transmembrane potential and antioxidant enzymes in heavy metal-induced apoptosis in fish cells. Intracellular calcium ion levels in both control and calcium ion treated cells were examined in the study. Cytofluorometric determination of mitochondrial transmembrance potential in both control and calcium ion treated cells were also performed. Results of the study demonstrated that increase in cytosolic calcium ions not only seems to be an early apoptotic signal mediator that play a fundamental role in initiating the final common pathways for the death program, but also it also plays a role in continuing the apoptotic processes.
- Subjects
CELLS; ENZYMES; CALCIUM ions; REACTIVE oxygen species; HEAVY metals; CYTOSOL; CYTOFLUOROMETRY
- Publication
Bulletin of Environmental Contamination & Toxicology, 2003, Vol 71, Issue 1, p0114
- ISSN
0007-4861
- Publication type
Article
- DOI
10.1007/s00128-003-0137-7