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- Title
CBL: MANY ADAPTATIONS TO REGULATE PROTEIN TYROSINE KINASES.
- Authors
Thien, Christine B. F.; Langdon, Wallace Y.
- Abstract
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
- Subjects
ONCOGENES; GENETIC transduction; MICROBIAL genetics; PROTEIN-tyrosine kinases; PROTEIN kinases
- Publication
Nature Reviews Molecular Cell Biology, 2001, Vol 2, Issue 4, p294
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/35067100