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- Title
The parallel lives of angiogenesis and immunosuppression: cancer and other tales.
- Authors
Motz, Gregory T.; Coukos, George
- Abstract
Emerging evidence indicates that angiogenesis and immunosuppression frequently occur simultaneously in response to diverse stimuli. Here, we describe a fundamental biological programme that involves the activation of both angiogenesis and immunosuppressive responses, often through the same cell types or soluble factors. We suggest that the initiation of these responses is part of a physiological and homeostatic tissue repair programme, which can be co-opted in pathological states, notably by tumours. This view can help to devise new cancer therapies and may have implications for aseptic tissue injury, pathogen-mediated tissue destruction, chronic inflammation and even reproduction.
- Subjects
NEOVASCULARIZATION; IMMUNOSUPPRESSION; CELL migration; ENDOTHELIAL growth factors; PROSTAGLANDINS; CELL metabolism; PROTEIN metabolism; CELL communication; CELL physiology; CELLS; COMPARATIVE studies; CONNECTIVE tissue cells; CYTOKINES; GROWTH factors; HOMEOSTASIS; IMMUNOLOGICAL tolerance; IMMUNOSUPPRESSIVE agents; RESEARCH methodology; MEDICAL cooperation; PROTEINS; RESEARCH; RESEARCH funding; T cells; TUMORS; EVALUATION research; PATHOLOGIC neovascularization; METABOLISM
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 10, p702
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3064