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- Title
Deubiquitylation and regulation of the immune response.
- Authors
Sun, Shao-Cong
- Abstract
Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune responses and many other biological processes. Similar to phosphorylation, ubiquitylation is a reversible process that is counter-regulated by ubiquitylating enzymes and deubiquitylating enzymes (DUBs). Despite the identification of a large number of DUBs, our knowledge of the function and activities of this family of enzymes is just starting to accumulate. As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses.
- Subjects
CELLULAR signal transduction; PHYSIOLOGICAL control systems; IMMUNOREGULATION; BACTERIAL transformation; CLINICAL enzymology; ENZYME inhibitors; PROTEIN metabolism; ANIMAL experimentation; B cells; COMPARATIVE studies; IMMUNITY; RESEARCH methodology; MEDICAL cooperation; PROTEOLYTIC enzymes; RESEARCH; T cells; EVALUATION research; SIGNAL peptides
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 7, p501
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2337