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- Title
The systematic analysis of protein-lipid interactions comes of age.
- Authors
Saliba, Antoine-Emmanuel; Vonkova, Ivana; Gavin, Anne-Claude
- Abstract
Lipids tailor membrane identities and function as molecular hubs in all cellular processes. However, the ways in which lipids modulate protein function and structure are poorly understood and still require systematic investigation. In this Innovation article, we summarize pioneering technologies, including lipid-overlay assays, lipid pull-down assays, affinity-purification lipidomics and the liposome microarray-based assay (LiMA), that will enable protein-lipid interactions to be deciphered on a systems level. We discuss how these technologies can be applied to the charting of system-wide networks and to the development of new pharmaceutical strategies.
- Subjects
PROTEIN-lipid interactions; SPHINGOLIPIDS; ISOPRENE; GLYCEROPHOSPHOLIPIDS; COAT proteins (Viruses)
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 12, p753
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm4080