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- Title
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
- Authors
Hardie, D. Grahame; Ross, Fiona A.; Hawley, Simon A.
- Abstract
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
- Subjects
HOMEOSTASIS; PROTEIN kinases; ADENOSINE triphosphate; METABOLISM; BIOENERGETICS; HYPOTHALAMUS; CELL cycle
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 4, p251
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3311