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- Title
Optimizing Treatment Quality in Head and Neck Cancer Therapy: Impact of Adaptive Intensity-Modulated Radiotherapy on Plan Quality and Tumor Volume Changes.
- Authors
Albosaabar, Muntather Habeeb; Ahmad, Rozilawati Binti; Alabedi, Haydar Hamza; Mohamed, Faizal; Yahya, Noorazrul; Abouelenein, Hassan; Mohamed, Dalia Osama; Sayed, Mona Mahmoud
- Abstract
Objective: This study examines the impact of volumetric alterations and PTV shifting on the quality of adaptive intensity-modulated radiation (IMRT) plans and their effectiveness in treating head and neck cancer. Methods: The research was carried out at the Sohag Cancer Centre in Egypt, including a sample of 36 individuals diagnosed with head and neck squamous cell carcinoma (HNSCC). Patients were chosen based on the following criteria: locally progressed and node-positive malignancy, oropharyngeal cancer, oral cavity cancer, and unknown primary. The research used dynamic intensity-modulated radiation therapy (D-IMRT) to establish treatment plans and SIEMENS SOMATOM DEFINITION CT scanners to acquire 3D anatomical images. The median dosage per fraction was observed at 1.64 to 2.12 Gy. Using the conformance index (CI) and the homogeneity index (HI), the quality of the plan was assessed. The threshold for statistical significance was set at 0.05. Results: The study analyzed patients with unilateral and bilateral HNSCC tumors, with most having bilateral tumors. The findings demonstrated that the tumor PTV was significantly reduced as a consequence of the suggested adaptive radiation techniques. The homogeneity and conformity indexes were used to evaluate the plan's quality (HI). The maximal homogeneity index (HI) was reached at fractions 14 and 7, respectively. The correlation between the reduction of PTV and CI was initially positive after fraction 7 but became negative after fractions 14 and 21. It was also shown that HI is positively correlated with PTV changes after fractions 7 and 14, while it was negative after 21 fractions. Conclusion: The use of adaptive radiotherapy in intensity-modulated radiation therapy (IMRT) treatment planning improves plan quality and decreases error rates due to tumor margin movement. Following radiation fractions, PTV shifting affects the homogeneity index (HI).
- Subjects
EGYPT; HEAD &; neck cancer; INTENSITY modulated radiotherapy; CANCER treatment; ADAPTIVE radiation; OROPHARYNGEAL cancer; SQUAMOUS cell carcinoma
- Publication
Journal of Contemporary Medical Sciences, 2024, Vol 10, Issue 2, p150
- ISSN
2415-1629
- Publication type
Article
- DOI
10.22317/jcms.v10i2.1522