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- Title
Safety and tolerability of olanzapine compared with other antipsychotics in the treatment of elderly patients with schizophrenia: a naturalistic study
- Authors
Ciudad, Antonio; Montes, José-Manuel; Olivares, José-Manuel; Gómez, Juan-Carlos
- Abstract
Objective. – To evaluate the safety and tolerability of olanzapine in the treatment of elderly patients with schizophrenia.Methods. – A total of 135 outpatients with schizophrenia ≥60 years of age were treated with olanzapine (n = 105) or another antipsychotic (n = 30) and followed up for 6 months. Safety measures included the recording of spontaneous adverse events and extrapyramidal symptoms (EPS). Clinical status and effectiveness of the medications were measured using the Clinical Global Impressions-Severity of Illness and the Global Assessment of Function (GAF) scales. Quality of life was assessed by means of the Spanish version of the EuroQol. The Awad scale was applied to evaluate patients’ subjective attitude towards medication.Results. – The incidence of overall adverse events and EPS was non-significantly lower in patients treated with olanzapine than in patients treated with other antipsychotics. The use of anticholinergic drugs was significantly lower (P = 0.04) in patients treated with olanzapine. Both groups of patients experienced similar improvements in Clinical Global Impressions-Severity and GAF scores. Non-significantly greater improvement in the acceptance of medication occurred at endpoint in olanzapine-treated patients than in control patients as measured by the Awad scale. The improvement in the EuroQol quality of life scale achieved at the end of study did not differ between both treatment groups.Conclusions. – Results from this naturalistic study showed that olanzapine was as safe and effective as other antipsychotic drugs in the treatment of elderly patients with schizophrenia.
- Subjects
SCHIZOPHRENIA treatment; PSYCHIATRIC drugs; OLANZAPINE; QUALITY of life
- Publication
European Psychiatry, 2004, Vol 19, Issue 6, p358
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/j.eurpsy.2004.06.008