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- Title
Evaluation of polypropylene mesh coated with biological hydrogels for temporary closure of open abdomen.
- Authors
Deng, Youming; Ren, Jianan; Chen, Guopu; Li, Guanwei; Guo, Kun; Hu, Qiongyuan; Wu, Xiuwen; Wang, Gefei; Gu, Guosheng; Li, Jieshou
- Abstract
Polypropylene mesh, as a temporary abdominal closure device, may cause mechanical intestine injury and inflammatory response. Chitosan/gelatin hydrogel has excellent biocompatibility, soft and elastic properties. This work is to assess the effects of the chitosan/gelatin hydrogel coated polypropylene mesh on open abdomen wounds. Histological analysis and detection of healing-related factors were conducted to evaluate the inflammation and wound healing process. After 1-day implantation in a murine model of open abdomen, the coated polypropylene mesh, compared with simple polypropylene mesh, demonstrated well protection of the intestine serosa. After 14-day implantation, it reduced the inflammation response by down-regulating the cytokines interleukin-6 and tumor necrosis factor-α, and up-regulating the anti-inflammatory factor interleukin-10. Meanwhile, the composite stimulated granulation tissue growth, and promoted matrix deposition and angiogenesis after 7 and 14 days. In conclusion, the modified temporary abdominal closure composite could significantly protect the intestines from mechanical damage and accelerate wound healing.
- Subjects
POLYPROPYLENE; HYDROGELS; ABDOMEN; INTESTINAL injuries; INFLAMMATION
- Publication
Journal of Biomaterials Applications, 2016, Vol 31, Issue 2, p302
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328216645950