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- Title
THE ASSOCIATION OF SERUM LEVEL OF IRISIN AND UROTENSIN II WITH INSULIN RESISTANCE IN PATIENTS WITH PREECLAMPSIA.
- Authors
Mansoor, Zainab Kamil; Saadoon, Wasan Taha; Abdulrasul, Enas A.
- Abstract
Maternal insulin resistance (IR) can be associated with a significant increased risk of subsequent preeclampsia, therefore finding biomarkers thatgive anearly diagnosis of insulin resistance during pregnancy can predict preeclampsia. The objective of this study is toevaluate the use of irisin and urotensin II (UII) as potential biomarkers for insulin resistance, which may assist in the early prediction of preeclampsia. This study is a case-control study conducted at maternity section in ALEmamain AL-Kadhemain medical city hospital, Baghdad, Iraq from June 2019 to January2020. A total of 90 pregnant women in their third trimester were included in this study and were divided into three groups according to the obtained results from all participant of laboratory investigations including fasting serum insulin and blood glucose and Homeostatic model assessment (HOMA) in which; 30 preeclamptic women with insulin resistance, 30 preeclamptic women without insulin resistance and 30 healthy pregnant women served as a control group participated in this study. Serum irisin, urotensin II (UII) and serum insulin levels were measured in all participants by enzyme linked immunosorbent assay method (ELISA). Irisin levels in preeclamptic patients with insulin resistance were significantly lower than its level in the other groups i.e., preeclamptic patients without insulin resistance and normal controls. On the other hand, serum UII was significantly higher in preeclamptic women in both groups than controls. There was no relationship between serum urotensin II UII and irisin levels. In preeclamptic patients with insulin resistance, serum irisin has shown three significant inverse correlations: with BMI (r= -0.482, p= 0.007), FBS (r= - 0.375, p= 0.041) and HOMA-IR (r= -0.374, p= 0.042). While, serum UII had only one significant positive correlation with HOMA-IR (r= 0.347, p= 0.047)).The current study concluded that serum irisin'sassociations with insulin resistance make it an excellentcandidate biomarker for insulin resistance in preeclamptic pregnant women. Serum urotensin II(UII)could be used as a biomarker for preeclampsia.
- Subjects
INSULIN resistance; UROTENSINS; PREECLAMPSIA; BIOMARKERS; ENZYME-linked immunosorbent assay
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, Issue 2, p5655
- ISSN
0972-5075
- Publication type
Article