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- Title
THE EFFECTS OF SAMBUCUS NIGRA EXTRACT IN EXPERIMENTAL ARTERIAL HYPERTENSION.
- Authors
Ciocoiu, Manuela; Serban, D.; Bădescu, L.; Tutunaru, Dana; Badulescu, Oana; Bădescu, Magda
- Abstract
It is known that natural polyphenols posses such physical and chemical properties that contribute to a proper and efficient protection from oxidation of important biomolecules such as lipids, proteins and nucleic acids. The evaluation of the intensity of oxidative stress in arterial hypertension experimentally induced via the administration of L-NAME was conducted with the help of specific enzymatic determinations and non-specific markers. The findings showed the antioxidant and protective effect of the Sambucus nigra extract on biochemical parameters, as well as on histopathological modifications in experimental arterial hypertension. The serous activity of glutathione-peroxidase and superoxide-dismutase has significantly lower values in the hypertensive group as compared to the group protected by polyphenols. The knowing of the effects of polyphenols on the functionality of endothelial cells, including membrane sensitivity and intracellular signaling, could lead to the use of the polyphenolic extract of Sambucus nigra as a nutritional supplement in chronic cardiovascular and metabolic diseases.
- Subjects
EUROPE; EUROPEAN elder; HYPERTENSION; OXIDATIVE stress; POLYPHENOLS; BIOMOLECULES; NUCLEIC acids; GLUTATHIONE
- Publication
Annals of the Romanian Society for Cell Biology, 2010, Vol 15, Issue 2, p87
- ISSN
2067-3019
- Publication type
Article