We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The impact of scrambler therapy on pain and quality of life for chemotherapy‐induced peripheral neuropathy: A pilot study.
- Authors
Chung, Matthew; Chen, Tsun Hsuan; Wang, Xin Shelley; KIM, Kyung‐Hoon; Abdi, Salahadin
- Abstract
Background: Chemotherapy‐induced peripheral neuropathy (CIPN) is a debilitating disturbance among patients who received chemotherapy, with no effective treatment available. Scrambler therapy (ST) is a noninvasive treatment capable of improving multiple quality‐of‐life symptoms beyond pain. We aimed to evaluate the efficacy of ST for pain and nonpain symptoms related to CIPN. Methods: Ten patients with moderate to severe CIPN symptoms for >3 months were enrolled in a single‐arm trial of ST for 10 daily sessions. CIPN‐related symptoms were measured throughout the treatment period and up to 6 months thereafter. Results: The worst pain was reduced by 6 months (p = 0.0039). QST demonstrated the greatest improvement in pressure of 60 g (p = 0.308, Cohen's d = 0.42) and cold temperature threshold of 2.5°C (p = 0.9375, Cohen's d = 0.51) in the gastrocnemius area. Symptoms of numbness, tingling, trouble walking, and disturbed sleep had significant improvements at 6 months. Pain medication use decreased by 70% at the end of treatment and by 42% at 6 months. Patient satisfaction was high (82%) and no adverse events with ST treatment were reported. Conclusions: The results of this pilot trial support the use of ST by demonstrating improvement in multiple domains of quality of life for CIPN patients during an extended follow‐up of 6 months. However, further large‐scale studies are needed to confirm our findings.
- Subjects
PAIN management; TREATMENT of peripheral neuropathy; PERIPHERAL neuropathy; ELECTROTHERAPEUTICS; PAIN measurement; EFFECT sizes (Statistics); T-test (Statistics); DATA analysis; RESEARCH funding; PILOT projects; QUESTIONNAIRES; CLINICAL trials; TREATMENT effectiveness; DESCRIPTIVE statistics; CANCER chemotherapy; LONGITUDINAL method; CANCER pain; QUALITY of life; STATISTICS; PATIENT satisfaction; DATA analysis software; CONFIDENCE intervals; TIME; SLEEP disorders
- Publication
Pain Practice, 2024, Vol 24, Issue 5, p749
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.13355