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- Title
Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report.
- Authors
Hara, Takeo; Fujiwara, Yoshiyuki; Takahashi, Hidenori; Sugimura, Keijiro; Moon, Jeong-Ho; Omori, Takeshi; Miyoshi, Norikatsu; Tomokuni, Akira; Akita, Hirofumi; Kobayashi, Shogo; Yasui, Masayoshi; Miyata, Hiroshi; Ohue, Masayuki; Sakon, Masato; Tomita, Yasuhiko; Yano, Masahiko
- Abstract
Background: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were treated with surgery and transcatheter arterial chemoembolization (TACE) that later recurred in the stomach. Case presentation: A 45-year-old female with severe anaemia was referred to our hospital. Computed tomography (CT) demonstrated a hypervascular tumour, 17 cm in diameter, that was in the tail of the pancreas. In addition, there were multiple hypervascular tumours in the liver. She underwent a distal pancreatectomy with splenectomy after the liver metastases were treated with TACE. Pathology confirmed that the pancreatic tumour was MAEC. After 4.5 years, a follow-up CT showed a hypervascular tumour at the upper part of the stomach. Gastric endoscopy showed a big tumefactive lesion with surface irregularities, gastric erosion, and multiple dilated vessels in the fornix and greater curvature of the stomach. She underwent a proximal gastrectomy and survived 7 years and 2 months after the start of the treatment. Conclusions: This is the first report of a metastatic stomach tumour from pancreatic MAEC, which was successfully treated with a multidisciplinary approach. Additionally, we review the literature and discuss the treatment of MAEC.
- Subjects
PANCREATIC cancer treatment; ENDOCRINE gland cancer; CELL differentiation; PANCREATIC acinar cells; CHEMOEMBOLIZATION
- Publication
Surgical Case Reports, 2017, Vol 3, Issue 1, p1
- ISSN
2198-7793
- Publication type
Article
- DOI
10.1186/s40792-017-0326-y