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- Title
Adiponectin preserves metabolic fitness during aging.
- Authors
Na Li; Shangang Zhao; Zhuzhen Zhang; Yi Zhu; Gliniak, Christy M.; Vishvanath, Lavanya; An, Yu A.; May-yun Wang; Yingfeng Deng; Qingzhang Zhu; Bo Shan; Sherwood, Amber; Onodera, Toshiharu; Oz, Orhan K.; Gordillo, Ruth; Gupta, Rana K.; Ming Liu; Horvath, Tamas L.; Dixit, Vishwa Deep; Scherer, Philipp E.
- Abstract
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced agerelated tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.
- Subjects
AGING; GLUCOSE metabolism disorders; LIPID metabolism disorders; INSULIN sensitivity; LABORATORY mice; ADIPONECTIN
- Publication
eLife, 2021, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.65108