We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients.
- Authors
Oliveira Martins, Caroline Alves; Do Val Guimarães, Isabel Cristina Chulvis; Velarde, Luis Guillermo Coca
- Abstract
Background This study aimed to analyze the relationship between the several risk factors for human papillomavirus ( HPV) infection and its persistence and to assess the prevalence of the lower genital tract precursor lesions, cancer, and HPV infection in female transplant recipients, besides the most prevalent HPV types. Methods The methodology adopted was a cross-sectional study with a random sample of 61 patients. Results The results indicated 10 cases (16.4%) of lesions, 54.5% of the overall prevalence of HPV infection, and HPV 16 was the most common high-risk HPV type, followed by HPV 51/53/70. A multiple logistic regression was done and hormone use presented a statistically significant association with high-risk HPV infection ( P=.037). No statistically significant association was identified for the set of all factors with the lesions studied. Conclusions The high prevalence of HPV infection and its precursor lesions confirmed the importance of differential screening and follow-up of transplanted patients. Condom use must be encouraged. The study result also confirmed the importance of knowledge of the viral type, in order to analyze the impact of HPV immunization, particularly against HPV types that are not 16/18. The reasonable rate of other genotypes, besides the vaccine types, should be considered to evaluate vaccination strategies.
- Subjects
GENITALIA; PAPILLOMAVIRUS diseases; TRANSPLANTATION of organs, tissues, etc.; CERVICAL intraepithelial neoplasia; THERAPEUTICS; DISEASE risk factors
- Publication
Transplant Infectious Disease, 2017, Vol 19, Issue 4, pn/a
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12714