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- Title
Immunogenicity of a peptide-based vaccine for measles: a pilot evaluation in a mouse model.
- Authors
Quach, Huy Quang; Ratishvili, Tamar; Haralambieva, Iana H.; Ovsyannikova, Inna G.; Poland, Gregory A.; Kennedy, Richard B.
- Abstract
Although neutralizing antibody is an established correlate of protection for measles, T cell-mediated responses play at least two critical roles in immunity to measles: first, through provision of 'help' enabling robust humoral immune responses; and second, through clearance of measles virus-infected cells. Previously, we identified 13 measles-derived peptides that bound to human leukocyte antigen (HLA) molecules in Priess cells infected with measles virus. In this study, we evaluated the immunogenicity of these peptides in a transgenic mouse model. Our results demonstrated that these peptides induced Th1-biased immune responses at varying levels. Of the 13 peptides, the top four immunogenic peptides were further selected for a viral challenge study in mice. A vaccine based on a combination of these four peptides reduced morbidity and weight loss after viral challenge compared to placebo. Our results emphasize the potential of T cell-mediated, peptide-based vaccines against measles.
- Subjects
MEASLES vaccines; VACCINE immunogenicity; LABORATORY mice; HLA histocompatibility antigens; ANIMAL disease models; T cell receptors
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-69825-2