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- Title
Effects of Physical Exercise on Hepatic Biomarkers in Adult Individuals: A Systematic Review and Meta-Analysis.
- Authors
Lima dos Santos, Luciano; Pinto de Castro, Juliana Brandão; Gama Linhares, Diego; Barros dos Santos, Andressa Oliveira; de Souza Cordeiro, Lilliany; Joaquim Borba-Pinheiro, Claudio; de Souza Vale, Rodrigo Gomes
- Abstract
Objective: This study aimed to analyze the effects of physical exercise on hepatic biomarkers in adult individuals. Methods: We conducted a systematic review and meta-analysis following the PRISMA recommendations and registered in PROSPERO (CRD42022337749). MEDLINE (via PubMed), Scopus, SPORTDiscus, and Web of Science were searched, using the terms of the Medical Subject Headings (MeSH) "exercise", "liver diseases", and "biomarkers". Results: Fourteen studies achieved eligibility with a total of 485 participants. Interventions ranged from 4 to 12 weeks, lasting 24 to 90 minutes per session, with 3 to 5 sessions per week. Interventions with aerobic and resistance exercises, with or without a vibration device and diet implementation, demonstrated a reduction in different hepatic biomarkers, such as aspartate transferase (AST), alanine transferase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin (ALB), ferritin (Fe), and indirect bilirubin (Bil). The main results of the metaanalysis showed no significant difference in ALB, GGT, AST, and ALP. However, there was a significant difference in ALT (SMD: - 0.41; 95% CI: - 0.71 to -0.11; p = 0.008; I² = 0%). Conclusion: Physical exercise (e.g., resistance training, aerobic training, highintensity interval training) favored the reduction of AST, ALT, GGT, ALP, ALB, Fe, and Bil. This study pointed out that the regular practice of physical exercise can be an efficient and recommended strategy to minimize the deleterious effects of liver diseases.
- Subjects
AEROBIC exercises; NON-alcoholic fatty liver disease; EXERCISE physiology; HIGH-intensity interval training; INTERVAL training; MEDICAL subject headings; RESISTANCE training; MEDICAL terminology; BIOMARKERS; ISOMETRIC exercise
- Publication
Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación, 2023, Vol 49, p762
- ISSN
1579-1726
- Publication type
Article
- DOI
10.47197/retos.v49.98939