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- Title
Synthesis and Biological Evaluation of 2,4-Diaminoquinazolines as Potential Antitumor Agents.
- Authors
Alassaf, Mohammad A.; Selim, Khalid B.; Nasr, Magda N. A.
- Abstract
In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against a panel of four human cancer cell lines and for their DNA-binding affinity. Among the synthesized compounds, 4c and 5b with 4-substitution at the phenyl ring were found to have the highest inhibitory effects against breast adenocarcinoma (MCF-7), colon cancer (HCT-116), hepatocellular carcinoma (HePG-2), and human skin cancer (HFB4). Further investigation revealed that compounds 4a and 5d exhibited better affinity to bind with DNA than other tested compounds.
- Subjects
BIOSYNTHESIS; ANTINEOPLASTIC agents; SKIN cancer; CHEMICAL synthesis; COLON cancer
- Publication
Journal of Chemistry, 2022, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2022/7763545