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- Title
Marula oil nanoemulsion improves motor function in experimental parkinsonism via mitigation of inflammation and oxidative stress.
- Authors
Alshaman, Reem; Qushawy, Mona; Mokhtar, Hatem I.; Ameen, Angie M.; El-Sayed, Rehab M.; Alamri, Eman Saad; Elabbasy, Lamiaa M.; Helaly, Ahmed M. N.; Elkhatib, Walid F.; Alyahya, Eidah M.; Zaitone, Sawsan A.
- Abstract
Introduction: Parkinson's disease (PD) is a neurologic condition exhibiting motor dysfunction that affects old people. Marula oil (M-Oil) has been used longley in cosmetics and curing skin disorders. M-Oil is particularly stable due to its high concentration of monounsaturated fatty acids and natural antioxidants. The current study formulated M-Oil in an o/w nanoemulsion (M-NE) preparations and tested its anti-inflammatory and antioxidant actions against experimental parkinsonism. Methods: Four experimental groups of male albino mice were used and assigned as vehicle, PD, PD + M-Oil and PD + M-NE. Locomotor function was evaluated using the open field test and the cylinder test. Striatal samples were used to measure inflammatory and oxidative stress markers. Results: The results indicated poor motor performance of the mice in PD control group then, improvements were recorded after treatment with crude M-Oil or MNE. In addition, we found high expression and protein of inflammatory markers and malondialdehyde levels in PD group which were downregulated by using doses of crude M-Oil or M-NE. Hence, formulating M-Oil in form of M-NE enhanced its physical characters. Discussion: This finding was supported by enhanced biological activity of M-NE as anti-inflammatory and antioxidant agent that resulted in downregulation of the inflammatory burden and alleviation of locomotor dysfunction in experimental PD in mice.
- Subjects
OXIDATIVE stress; PARKINSONIAN disorders; PARKINSON'S disease; MONOUNSATURATED fatty acids; NEUROLOGICAL disorders; EMULSIONS
- Publication
Frontiers in Pharmacology, 2023, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2023.1293306