We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insights of Chinese herbal medicine for mitochondrial dysfunction in chronic cerebral hypoperfusion induced cognitive impairment: Existed evidences and potential directions.
- Authors
Yefei Wang; Ying Wang; Shixin Li; Huihui Jin; Jiayu Duan; Xiyue Lu; Yinglin Qin; Jiale Song; Xiaoshan Li; Xianglan Jin
- Abstract
Chronic cerebral hypoperfusion (CCH) is one of the main pathophysiological markers of cognitive impairment in central nervous system diseases. Mitochondria are cores of energy generation and information process. Mitochondrial dysfunction is the key upstream factors of CCH induced neurovascular pathology. Increasing studies explored the molecular mechanisms of mitochondrial dysfunction and self-repair for effective targets to improve CCH-related cognitive impairment. The clinical efficacy of Chinese herbal medicine in the treatment of CCH induced cognitive impairment is definite. Existed evidences from pharmacological studies have further proved that, Chinese herbal medicine could improve mitochondrial dysfunction and neurovascular pathology after CCH by preventing calcium overload, reducing oxidative stress damage, enhancing antioxidant capacity, inhibiting mitochondriarelated apoptosis pathway, promoting mitochondrial biogenesis and preventing excessive activation of mitophagy. Besides, CCH mediated mitochondrial dysfunction is one of the fundamental causes for neurodegeneration pathology aggravation. Chinese herbal medicine also has great potential therapeutic value in combating neurodegenerative diseases by targeting mitochondrial dysfunction.
- Subjects
HERBAL medicine; CHINESE medicine; COGNITION disorders; CENTRAL nervous system diseases; MITOCHONDRIA
- Publication
Frontiers in Pharmacology, 2023, Vol 14, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2023.1138566