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- Title
The pivotal role of endoplasmic reticulum in FDG uptake in cancer cells.
- Authors
Vitale, Francesca; Ghelardoni, Maddalena; Chiesa, Sabrina; Carta, Sonia; Losacco, Serena; Orengo, Anna Maria; Bruno, Silvia; Ravera, Silvia; Bauckneht, Matteo; Riondato, Mattia; Donegani, Isabella; Dighero, Edoardo; Martinelli, Jonathan; Marini, Cecilia; Sambuceti, Gianmario
- Abstract
This article discusses the role of the endoplasmic reticulum (ER) in the uptake of FDG (fluorodeoxyglucose) in cancer cells. FDG is commonly used in PET imaging to detect cancer lesions. The study found that the transport of FDG-6P (phosphorylated FDG) across the ER membrane affects the retention and release of the tracer. Silencing the gene responsible for FDG-6P transport resulted in increased tracer retention and decreased washout rate. These findings suggest that FDG uptake in cancer cells is influenced by the competition between FDG-6P metabolism and hydrolysis within the ER.
- Subjects
ENDOPLASMIC reticulum; POSITRON emission tomography computed tomography; CANCER cells
- Publication
EJNMMI Research, 2024, Vol 14, Issue 1, p1
- ISSN
2191-219X
- Publication type
Article
- DOI
10.1186/s13550-024-01124-3