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- Title
Statistical characteristics of climbing fiber spikes necessary for efficient cerebellar learning.
- Authors
Kuroda, Shinya; Yamamoto, Kenji; Miyamoto, Hiroyuki; Doya, Kenji; Kawato, Mitsuo
- Abstract
Abstract. Mean firing rates (MFRs), with analogue values, have thus far been used as information carriers of neurons in most brain theories of learning. However, the neurons transmit the signal by spikes, which are discrete events. The climbing fibers (CFs), which are known to be essential for cerebellar motor learning, fire at the ultra-low firing rates (around I Hz), and it is not yet understood theoretically how high-frequency information can be conveyed and how learning of smooth and fast movements can be achieved. Here we address whether cerebellar learning can be achieved by CF spikes instead of conventional MFR in an eye movement task, such as the ocular following response (OFR), and an arm movement task. There are two major afferents into cerebellar Purkinje cells: parallel fiber (PF) and CF, and the synaptic weights between PFs and Purkinje cells have been shown to be modulated by the stimulation of both types of fiber. The modulation of the synaptic weights is regulated by the cerebellar synaptic plasticity. In this study we simulated cerebellar learning using CF signals as spikes instead of conventional MFR. To generate the spikes we used the following four spike generation models: (1)...
- Subjects
NEURONS; LEARNING; PURKINJE cells; PHYSIOLOGICAL adaptation
- Publication
Biological Cybernetics, 2001, Vol 84, Issue 3, p183
- ISSN
0340-1200
- Publication type
Article
- DOI
10.1007/s004220000206