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- Title
Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations.
- Authors
Obrist, Walter D; Zhang, Zihong; Yonas, Howard
- Abstract
SummaryComputer simulations of stable xenon (SXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography. Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4.5 minutes of SXe inhalation. The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation. In contrast to the peak 35% increase in blood flow velocity during SXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.Journal of Cerebral Blood Flow & Metabolism (1998) 18, 1192-1195; doi:10.1097/00004647-199811000-00005
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1998, Vol 18, Issue 11, p1192
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-199811000-00005