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- Title
Inactivating mutations of CASPASE-7 gene in human cancers.
- Authors
Young Hwa Soung, Allen C.; Jong Woo Lee; Hong Sug Kim; Won Sang Park; Su Young Kim; Jong Heun Lee; Jik Young Park; Yong Gu Cho, Allen C.; Chang Jae Kim, Allen C.; Yong Gyu Park; Suk Woo Nam; Seong Whan Jeong, Allen C.; Sang Ho Kim; Jung Young Lee; Nam Jin Yoo; Sug Hyung Lee
- Abstract
Caspase-7 is a caspase involved in the execution phase of apoptosis. To explore the possibility that the genetic alterations of CASPASE-7 might be involved in the development of human cancers, we analysed the entire coding region and all splice sites of human CASPASE-7 gene for the detection of somatic mutations in a series of human solid cancers, including carcinomas from stomach, colon, head/neck, esophagus, urinary bladder and lung. Overall, we detected CASPASE-7 mutations in two of 98 colon carcinomas (2.0%), one of 50 esophageal carcinomas (2.0%) and one of 33 head/neck carcinomas (3.0%). We expressed the tumor-derived caspase-7 mutants in 293?T cells and found that the apoptosis was reduced compared to the wild-type caspase-7. This is the first report on the CASPASE-7 gene mutations in human malignancies, and our data suggest that the inactivating mutations of the CASPASE-7 gene might lead to the loss of its apoptotic function and contribute to the pathogenesis of some human solid cancers.Oncogene (2003) 22, 6104-6108. doi:10.1038/sj.onc.1206727
- Subjects
APOPTOSIS; CELL death; CANCER; GENES; GENETIC mutation
- Publication
Oncogene, 2003, Vol 22, Issue 39, p6104
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1206727