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- Title
Toxic Effects of Copper on Antioxidative and Metabolic Enzymes of the Marine Gastropod, Onchidium struma.
- Authors
Li, Xiao-bo; Hou, Xue-li; Mao, Qian; Zhao, Yun-long; Cheng, Yong-xu; Wang, Qun
- Abstract
The goals of this study were to evaluate the acute and sublethal toxicity of copper (Cu2+) on the marine gastropod, Onchidium struma, and to examine the utility of enzymatic parameters as indicators of Cu2+ exposure. In a semistatic renewal test, the 96-hour median lethal concentration of Cu2+ for O. struma, 74.80 mg/L, was higher than that for other intertidal species. The activities of the antioxidative enzymes, Cu/Zn superoxide dismutase (Cu/Zn-SOD) and catalase (CAT), and those of the metabolic enzymes-acid phosphatase (ACP), alkaline phosphatase (AKP), glutamic-oxaloacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) -in both hepatopancreas and muscle were determined after a 1-week exposure to Cu2+ (range 1.35 to 4.20 mg/L). The activities of both Cu/Zn-SOD and CAT were higher in hepatopancreas than muscle. In addition, there was a negative correlation between Cu2+ concentration and Cu/Zn-SOD activity in hepatopancreas, whereas a positive correlation was observed for CAT activity. Concentration-dependent changes in ACP and AKP activity showed a similar trend in hepatopancreas, increasing then decreasing and, finally, a slight increase. In contrast, ACP activity was positively correlated with Cu2+ across the concentration range tested. In both hepatopancreas and muscle, both GOT and GPT were activated by lower concentrations of Cu2+ and inhibited at higher concentrations.
- Subjects
COPPER &; the environment; PHYSIOLOGICAL effects of copper; COPPER poisoning; ANTIOXIDANTS; METABOLISM; ENZYMES; GASTROPODA; PHYSIOLOGICAL effects of water pollution; TOXICOLOGY of water pollution
- Publication
Archives of Environmental Contamination & Toxicology, 2009, Vol 56, Issue 4, p776
- ISSN
0090-4341
- Publication type
Article
- DOI
10.1007/s00244-009-9290-2