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- Title
Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies.
- Authors
Mansor, Syahir; Boellaard, Ronald; Huisman, Marc; van Berckel, Bart; Schuit, Robert; Windhorst, Albert; Lammertsma, Adriaan; van Velden, Floris; Huisman, Marc C; van Berckel, Bart N M; Schuit, Robert C; Windhorst, Albert D; Lammertsma, Adriaan A; van Velden, Floris H P
- Abstract
<bold>Purpose: </bold>The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles.<bold>Procedures: </bold>Healthy subjects received dynamic HRRT scans using either (R)-[(11)C]verapamil (n = 5), [(11)C]raclopride (n = 5) or [(11)C]flumazenil (n = 5). To reduce the effects of patient motion on scatter scaling factors, a margin in the attenuation correction factor (ACF) sinogram was applied prior to 2D or 3D single scatter simulation (SSS).<bold>Results: </bold>Some (R)-[(11)C]verapamil studies showed prominent artefacts that disappeared with an ACF-margin of 10 mm or more. Use of 3D SSS for (R)-[(11)C]verapamil showed a statistically significant increase in volume of distribution compared with 2D SSS (p < 0.05), but not for [(11)C]raclopride and [(11)C]flumazenil studies (p > 0.05).<bold>Conclusions: </bold>When there is a patient motion-induced mismatch between transmission and emission scans, applying an ACF-margin resulted in more reliable scatter scaling factors but did not change (and/or deteriorate) quantification.
- Subjects
BRAIN; DIAGNOSIS of brain diseases; MEDICAL radiography; BRAIN injuries; RADIOGRAPHY; COMPUTED tomography; MOTION; SCATTERING (Physics); POSITRON emission tomography
- Publication
Molecular Imaging & Biology, 2016, Vol 18, Issue 4, p627
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-015-0921-x