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- Title
Human polynucleotide phosphorylase (hPNPase<sup>old-35</sup>): an evolutionary conserved gene with an expanding repertoire of RNA degradation functions.
- Authors
Das, S K; Bhutia, S K; Sokhi, U K; Dash, R; Azab, B; Sarkar, D; Fisher, P B
- Abstract
Human polynucleotide phosphorylase (hPNPaseold-35) is an evolutionary conserved RNA-processing enzyme with expanding roles in regulating cellular physiology. hPNPaseold-35 was cloned using an innovative 'overlapping pathway screening' strategy designed to identify genes coordinately regulated during the processes of cellular differentiation and senescence. Although hPNPaseold-35 structurally and biochemically resembles PNPase of other species, overexpression and inhibition studies reveal that hPNPaseold-35 has evolved to serve more specialized and diversified functions in humans. Targeting specific mRNA or non-coding small microRNA, hPNPaseold-35 modulates gene expression that in turn has a pivotal role in regulating normal physiological and pathological processes. In these contexts, targeted overexpression of hPNPaseold-35 represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions.
- Subjects
NUCLEIC acids; PHOSPHORYLASES; CELL differentiation; GENE expression; GENE targeting; CELL physiology; GENETIC regulation
- Publication
Oncogene, 2011, Vol 30, Issue 15, p1733
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2010.572