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- Title
Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis.
- Authors
Engen, Phillip A.; Zaferiou, Antonia; Rasmussen, Heather; Naqib, Ankur; Green, Stefan J.; Fogg, Louis F.; Forsyth, Christopher B.; Raeisi, Shohreh; Hamaker, Bruce; Keshavarzian, Ali
- Abstract
Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients.
- Subjects
MULTIPLE sclerosis; GUT microbiome; PATHOLOGY; FECAL microbiota transplantation; SHORT-chain fatty acids; MULTIPLE sclerosis treatment
- Publication
Frontiers in Neurology, 2020, Vol 11, pN.PAG
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2020.00978