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- Title
Development of Stimulus‐Responsive Degradable Film via Codeposition of Dopamine and Cystamine.
- Authors
Jeong, Wonwoo; Kim, Eunseok; Jeong, Jaehoon; Bisht, Himani; Kang, Hyeongeun; Hong, Daewha
- Abstract
Herein, we report a degradable film that can be coated on various substrates by the codeposition of dopamine and cystamine. The thickness of the resulting film (pDC) varies depending on the initial ratio of dopamine/cystamine dissolved in a solution; the thickest film (ca. 60 nm) is obtained under optimized codeposition conditions. Selective degradation of pDC occurs in the presence of tris(2‐carboxyethyl)phosphine (TCEP), the reaction kinetics of which are highly dependent on the TCEP concentration. For further application as a drug‐delivery platform, doxorubicin can be loaded within the pDC film, which is released actively under film degradation in response to TCEP. We expect that the developed pDC film will be a useful tool for developing drug delivery cargo, antibacterial surface, and cell surface coating for various biomedical applications.
- Subjects
THICK films; CHEMICAL kinetics; SURFACE coatings; DOPAMINE; CELL membranes; DOXORUBICIN
- Publication
Chemistry - An Asian Journal, 2020, Vol 15, Issue 17, p2622
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202000216