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- Title
Retrospective Comparison of Institutional Cytological Accuracy in Warthin Tumour Diagnosis.
- Authors
Stueck, Ashley; Taylor, S. Mark; Hart, Robert D.; Trites, Jonathan R.; Bullock, Martin J.
- Abstract
Purpose: We hypothesize that cytological accuracy in diagnosis of Warthin tumour (WT) at our institution has improved over time. Study Design and Methods: A retrospective review of patients with a WT diagnosis and both fine-needle aspirate (FNA) and surgical specimens was completed for the past 8 years. All FNA specimens were prepared using a thin-layer technique. For the review, 82 patients were identified and divided into two groups based on date of FNA. True-positive (TP), false-positive (FP), and false-negative (FN) rates were calculated. Parameter of FN versus TP parameters and TP versus FP results were compared. Results: Our institution has improved TP rates over time (p ≤ .046). FN FNAs were more likely to have other cellular components (p ≤ 10-5), less likely to have oncocytes (p ≤ 10-5) and lymphocytes (p ≤ 10-5), and had a smaller tumour size at resection (p ≤ 0.03), compared with TP cases. FP for WT cases were more likely to occur in nonparotid locations (p ≤ .0006). Parotid FNAs FP for WT were acinic cell carcinoma and low-grade mucoepidermoid carcinoma. Conclusions: Cytological diagnosis of WT has improved at our institution. Associated factors include educational initiatives and changes in FNA practices by the head and neck surgeons. Mimics and key differentiating factors are reviewed.
- Subjects
TUMOR diagnosis; NEEDLE biopsy; CANCER diagnosis; ONCOLOGIC surgery; SURGICAL excision
- Publication
Canadian Journal of Pathology, 2014, Vol 6, Issue 4, p126
- ISSN
1918-915X
- Publication type
Article