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- Title
Study on serum cytokine levels in posttraumatic stress disorder patients
- Authors
Guo, Min; Liu, Tao; Guo, Jun-Cheng; Jiang, Xiang-Ling; Chen, Feng; Gao, Yun-Suo
- Abstract
Abstract: Objective: To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α levels in posttraumatic stress disorder (PTSD) patients. Methods: We utilized ELISA technology to examine cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α in serum from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, and 50 age- and gender-matched healthy controls. We conservatively employed a Mann-Whitney U testing. Results: Individuals with primary PTSD had significantly elevated peripheral cytokine levels for all 6 different cytokines compared to age- and gender-matched healthy controls (all P<0.01). Conclusions: These findings suggest that a generalized inflammatory state may be present in individuals with PTSD.
- Subjects
SERUM; CYTOKINES; POST-traumatic stress disorder; TUMOR necrosis factors; ENZYME-linked immunosorbent assay; MEDICAL technology; NEUROSES diagnosis; PATIENTS
- Publication
Asian Pacific Journal of Tropical Medicine, 2012, Vol 5, Issue 4, p323
- ISSN
1995-7645
- Publication type
Article
- DOI
10.1016/S1995-7645(12)60048-0