We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark.
- Authors
NIELSEN, Pia Rude; ERIKSEN, Jens Ole; WEHKAMP, Ulrike; LINDAHL, Lise Maria; GNIADECKI, Robert; FOGH, Hanne; FABRICIUS, Susanne; BZOREK, Michael; ØDUM, Niels; GJERDRUM, Lise Mette Rahbek
- Abstract
Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathological data for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients' mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01). All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8-) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.
- Subjects
DENMARK; SEZARY syndrome; SKIN disease diagnosis; CUTANEOUS T-cell lymphoma; MYCOSIS fungoides
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 13, p1231
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3351