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- Title
Correlation Between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis Treated with Ustekinumab.
- Authors
HESSELVIG, Jeanette Halskou; EGEBERG, Alexander; LOFT, Nikolai Dyrberg; ZACHARIAE, Claus; KOFOED, Kristian; SKOV, Lone
- Abstract
Monitoring of biological treatment efficacy for psoriasis is based on clinical evaluation and patient's quality of life. However, long-term correlation between Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) in real life has not been studied in patients treated with ustekinumab. All patients with psoriasis treated with ustekinumab at our department were included (n = 120) in this study. Correlation analyses between the change in PASI and DLQI and the individual subquestions in DLQI were performed using Spearman's rank correlation coefficient. A correlation value of 0.57 (p-value < 0.001) and 0.45 (p-value < 0.001) between PASI and DLQI were found in the period baseline months and baseline 12 months, respectively. In DLQI subquestions, the greatest association was found for the questions on "Symptoms and feelings". Objective improvements in the severity of psoriasis were weakly to moderately associated with improvements in quality of life in patients with psoriasis treated with ustekinumab.
- Subjects
PSORIASIS treatment; QUALITY of life; SEVERITY of illness index; TREATMENT effectiveness; STATISTICAL correlation
- Publication
Acta Dermato-Venereologica, 2018, Vol 98, Issue 3, p335
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2833