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- Title
Biological biomarkers of cancer prognosis.
- Abstract
Antibody-based detection methods have allowed the evaluation of many biological compounds for clinical importance in cancer prognosis. These include proteins in bodily fluids, proteins in tumor tissue or lymph nodes, and cell types identifiable by protein expression. We systematically summarized the literature on uncommon molecular biomarkers associated with cancer outcome. A literature search was conducted on Medline and Embase utilizing keywords such as "cancer," "inflammation," "prognosis," inflammation" and "biomarkers." Articles that reported on uncommon biological biomarkers of prognosis were selected for inclusion. Information regarding the cancer type, interventions received, and the impact on prognosis and significance was extracted. A total of 28 studies comprising of 5,234 patients found associations between 45 uncommon molecular biomarkers and prognosis in more than 15 types of primary malignancies. Many molecular biomarkers found to be associated with prognosis are part of the overlapping pathways of inflammation and oxidative stress. Identification of prognostic biomarkers has the potential to highlight aspects of physiology that lead to poor prognosis and assist in the identification of therapeutic targets.
- Subjects
TUMOR prognosis; BIOMARKERS; INFLAMMATION; MEDICAL information storage &; retrieval systems; MEDLINE; SYSTEMATIC reviews
- Publication
Journal of Pain Management, 2017, Vol 10, Issue 3, p309
- ISSN
1939-5914
- Publication type
Article