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- Title
Isoegomaketone From Perilla frutescens Ameliorates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.
- Authors
Kim, Ye-Ram; Han, Ah-Reum; Kim, Jin-Baek; Cao, Shugeng; Jin, Chang Hyun
- Abstract
Inflammatory bowel disease (IBD) is a worldwide health problem. An effective treatment for IBD is unavailable, and potential therapeutic agents should be developed for treating colonic inflammation. In this study, we demonstrated that isoegomaketone (IK), an essential oil component of a mutant cultivar of Perilla frutescens produced through radiation breeding, reduced levels of inflammatory cytokines, such as tumor necrosis factor-α, interleukin-6, interleukin-10, and interleukin-12p40, in lipopolysaccharide-stimulated mouse primary macrophages. Furthermore, when 5 mg/kg IK was administered to mice with dextran sodium sulfate-induced colitis, it ameliorated the severity of the disease as assessed by survival, body weight, and colonic damage. These results suggested that 5 mg/kg IK has a preventive effect in colitis and can be a novel alternative therapy for treating colitis.
- Subjects
PERILLA frutescens; ULCERATIVE colitis; INFLAMMATORY bowel diseases; SODIUM; COLITIS; MICE
- Publication
Natural Product Communications, 2022, Vol 17, Issue 6, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X221105694