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- Title
Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine- Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study.
- Authors
Dastgheib, Ladan; Rostami, Farima; Gharesi-Fard, Behrouz; Asadi-Pooya, Ali Akbar; Namjoo, Saba; Tahmasebi, Foroozan; Hadibarhaghtalab, Maryam
- Abstract
Background: Genetic diversity in human leukocyte antigen (HLA) alleles across populations is a significant risk factor for drug-induced severe cutaneous adverse reactions (SCARs), e.g., carbamazepine (CBZ)- and lamotrigine (LTG)-induced Stevens- Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The present study aimed to investigate the frequency of different HLA alleles in Iranian patients with CBZ- and LTG-induced SJS/TEN. Methods: A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and divided into two groups. The drug-induced group (n=14) included hospitalized patients due to CBZ- or LTG-induced SJS/TEN. The drug-tolerant group (n=17) included individuals receiving CBZ or LTG for at least three months with no adverse effects. In addition, 46 healthy individuals (control group) were recruited. The frequency of HLA-A, -B, and -DRB1 alleles in patients with CZB- or LTG-induced SJS/TEN was investigated. HLA typing was performed using the allele-specific polymerase chain reaction method. The Chi square test and Fisher's exact test were used to determine a potential association between SJS/TEN and HLA alleles. P<0.05 was considered statistically significant. Results: CBZ- or LTG-induced SJS/TEN was not significantly associated with HLA alleles. However, HLA-DRB1*01 showed a significantly higher frequency in patients with CBZ-induced SJS/TEN than the CBZ-tolerant patients (30% vs. 9%, P=0.07). Conclusion: Overall, no significant association was found between CBZ- or LTG-induced SJS/TEN and HLA alleles. Further largescale studies are required to substantiate our findings.
- Subjects
IRAN; SKIN disease prevention; CARBAMAZEPINE; LAMOTRIGINE; ANTICONVULSANTS; HLA-B27 antigen; TOXIC epidermal necrolysis; ACADEMIC medical centers; TIME; ALLELES; STEVENS-Johnson Syndrome; CASE-control method; GENETIC variation; FISHER exact test; HISTOCOMPATIBILITY testing; PUBLIC health; CHI-squared test; DESCRIPTIVE statistics; POPULATION health; POLYMERASE chain reaction; DATA analysis software
- Publication
Iranian Journal of Medical Sciences, 2023, Vol 48, Issue 1, p70
- ISSN
0253-0716
- Publication type
Article
- DOI
10.30476/IJMS.2022.91192.2241