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- Title
Reacciones sistémicas relacionadas a la inmunoterapia con alergenos en Monterrey, México.
- Authors
González-Díaz, Sandra Nora; de la Rosa-López, Jorge Humberto; Arias-Cruz, Alfredo; Macías-Weinmann, Alejandra; Herrera-Castro, Dayanara; Rodríguez-Ortíz, Pablo; Rojas-Lozano, Alejandro; De Jesús García-Calderín, Diego
- Abstract
Background: Patients who receive allergen immunotherapy (IT) have a potential risk of systemic reactions, however such reactions are rare when IT administered properly. The frequency of systemic reactions (SR) due to conventional IT is less than 1%. Objective: To determine the frequency of secondary SR to allergen IT, and to identify the possible factors involved in developing them. Methods: A retrospective descriptive study that included 2.319 patients who received 14.600 allergen immunotherapy injections during the period from May 1, 2001 to April 30, 2002. Results: Twelve patients had a SR (age 7 - 40 years), all of which occurred within the first 30 minutes after the IT. These were more frequent during the dose - increase phase (58%). The frequency of (RS) in relation to the number of injections was 1:1216, and regarding to the number of patients, 1:193. The clinical manifestations included bronchospasm 83%, urticaria 67%, gastrointestinal symptoms and hypotension 8.3%. The 58% had anaphylaxis and pulmonary or dermatological symptoms only in 33% and 8.3% respectively. The possible factors involved in the onset of SR were: sensitivity identified by large skin reactions in skin test (PC) 83%, uncontrolled asthma 50%, application of allergens IT during high pollination season 42%, inadequate immunotherapy scheme monitoring 17%. Conclusions: The frequency of SR in this group of patients was low as that reported in other publications.
- Subjects
ALLERGENS; IMMUNOTHERAPY; URTICARIA; ANAPHYLAXIS; SKIN tests
- Publication
Revista Alergia de Mexico, 2011, Vol 58, Issue 2, p79
- ISSN
0002-5151
- Publication type
Article