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- Title
Identification of the toxic trigger in mushroom poisoning.
- Authors
Matsuura, Masanori; Saikawa, Yoko; Inui, Kosei; Nakae, Koichi; Igarashi, Masayuki; Hashimoto, Kimiko; Nakata, Masaya
- Abstract
We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.
- Subjects
EXPERIMENTAL toxicology; CARBOXYLIC acids; CHEMICAL reactions; MUSHROOMS; POLYMERIZATION
- Publication
Nature Chemical Biology, 2009, Vol 5, Issue 7, p465
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.179