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- Title
Interleukin-10: A Pleiotropic Regulator in Pregnancy.
- Authors
Cheng, Shi ‐ Bin; Sharma, Surendra
- Abstract
Pregnancy is a unique and well-choreographed physiological process that involves intricate interplay of inflammatory and anti-inflammatory milieu, hormonal changes, and cellular and molecular events at the maternal-fetal interface. IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining immune tolerance. A wide array of cell types including both immune and non-immune cells secret IL-10 in an autocrine and paracrine manner. IL-10 binds to a specific receptor complex and activates JAK- STAT and PI3K-Akt signaling pathways while inhibiting NF-κB signaling pathway. IL-10 exerts its anti-inflammatory effects mainly by decreasing pro-inflammatory cytokines such as IL-1, IL-6, IL-12, and TNF-α, by inducing heme oxygenase-1, and by inhibiting antigen presentation via blocking major histocompatibility complex ( MHC) class II expression. Prior studies from our group and others have shown that IL-10 also functions as a potent protector against vascular dysfunction, and enhancement of IL-10 may serve as an immunotherapeutic intervention to treat adverse pregnancy outcomes. This review seeks to critically evaluate the archetypal functions of IL-10 as an immune suppressive factor as well as its novel functions as a vascular protector and modulator of endoplasmic reticulum ( ER) stress and autophagy in the context of normal and adverse pregnancy outcomes.
- Subjects
INTERLEUKIN-10; PLEIOTROPHIN; PREGNANCY; MATERNAL-fetal exchange; IMMUNE response; MAJOR histocompatibility complex; ENDOPLASMIC reticulum
- Publication
American Journal of Reproductive Immunology, 2015, Vol 73, Issue 6, p487
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12329