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- Title
Intermittent High-Dose Glucocorticoid Treatment Does Not Cause Adrenal Insufficiency in Patients with Diffuse Large B-Cell Lymphoma: A Prospective Study.
- Authors
Einarsdottir, Margret Jona; Kristjansdottir, Hallgerdur L.; Bergthorsdottir, Ragnhildur; Johannsson, Gudmundur; Trimpou, Penelope; Lewerin, Catharina; Ragnarsson, Oskar
- Abstract
Glucocorticoid (GC) treatment suppresses the hypothalamic-pituitary-adrenal axis and can cause GC-induced adrenal insufficiency. In this study, we investigated the incidence of GC-induced adrenal insufficiency in patients receiving intermittent short-term high-dose oral GC treatment for newly diagnosed diffuse large B-cell lymphoma. Cosyntropin stimulation test was used to assess adrenal function at study entry (baseline), at 2 months (before the 5th cycle), and 6 months from baseline (3 months after the last cycle). Ten patients were included (40% women). Mean age was 61 years. The mean (range) plasma morning cortisol was 407 (320–530) nmol/L at baseline, 373 (260–610) nmol/L at 2 months, and 372 (230–520) nmol/L at 6 months from baseline. All patients had normal response to cosyntropin stimulation at baseline as well as 2 and 6 months from baseline. Thus, none of the patients developed biochemically verified adrenal insufficiency. Therefore, short-term high-dose GC therapy, a commonly used adjuvant treatment in patients with malignant hematological diseases, does not seem to down-regulate the hypothalamic-pituitary-adrenal axis.
- Subjects
DIFFUSE large B-cell lymphomas; ADRENAL insufficiency; BLOOD diseases; GLUCOCORTICOIDS; HYPOTHALAMIC-pituitary-adrenal axis
- Publication
Acta Haematologica, 2024, Vol 147, Issue 3, p360
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000534317