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- Title
Baohuoside I Inhibits Benzo(a)Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT.
- Authors
Khan, Muhammad; Maryam, Amara; Shakir, Hafiz Abdullah; Qazi, Javed Iqbal; Yongming Li
- Abstract
Benzo(a)pyrene (BaP), a major component of cigarette smoke, has been found to be a potent human carcinogen. Recently, it has been shown to induce lung cancer metastasis. In the present study, we found for the first time that Baohuoside I (BHS-1), a natural flavonol glycoside inhibits BaP-induced A549 lung cancer metastasis by modulating the expressions of p-STAT3, COX-2, MMP-2, MMP-9, E-cadherin and N-cadherin. Moreover, we found that chronic BaP exposure promoted migration without enhancing the proliferation of cells and BHS-I was equally toxic to both BaP-treated and untreated A549 cells. Taken together, the data of present study indicate that BHS-I not only inhibits metastasis but also induces cell death in BaP-treated A549 cells. Therefore, BHS-I may become a potential lead compound for treatment of lung adenocarcinoma.
- Subjects
BENZOPYRENE; LUNG cancer treatment; FLAVONOL glycosides; CELL proliferation; CADHERINS
- Publication
Pakistan Journal of Zoology, 2018, Vol 50, Issue 6, p2357
- ISSN
0030-9923
- Publication type
Article
- DOI
10.17582/journal.pjz/2018.50.6.2357.2365