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- Title
Norovirus infection as a model of chronic or recurrent infection in common variable immunodeficiency.
- Authors
Moral Moral, Pedro; Cabañero-Navalon, Dafne; Garcia-Bustos, Victor; Núñez Beltrán, María; Salavert Lletí, Miguel
- Abstract
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency (PID) in general population. PID are genetic diseases that share a dysfunction in the immune system entailing a greater risk of both chronic and recurrent infections. These patients can also develop chronic gastrointestinal infections caused by norovirus with persistent viral dissemination, which can be detected months after primoinfection. Additionally, a proportion of CVID patients show a typical severe enteropathy presenting with recurrent diarrhoea, intestinal malabsorption, inflammatory lesions, and villous atrophy. Some studies have related this enteropathy with chronic intestinal infection caused by norovirus.
- Subjects
IMMUNODEFICIENCY; NOROVIRUSES; INTESTINAL diseases; GASTROINTESTINAL diseases; DIARRHEA
- Publication
Revista Española de Quimioterapia, 2022, Vol 35, p63
- ISSN
0214-3429
- Publication type
Article
- DOI
10.37201/req/s03.14.2022