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- Title
Causal relationship between years of education and the occurrence of rheumatoid arthritis.
- Authors
Sang-Cheol Bae; Young Ho Lee; Bae, Sang-Cheol; Lee, Young Ho
- Abstract
<bold>Objective: </bold>To search out whether or not years of education is causally related to rheumatoid arthritis (RA).<bold>Method: </bold>We conducted a two-sample Mendelian randomisation (MR) analysis employing inverse-variance weighted (IVW), weighted median and MR-Egger regression analysis. We chose statistic data of years of education from the UK Biobank genome-wide association studies (GWASs) (n=293 723) as the exposure and a meta-analysis of GWASs of RA with autoantibody (n=5539) and European controls (n=20 169) as the outcome.<bold>Results: </bold>We selected a total of 49 single nucleotide polymorphisms as instrumental variables (IVs). The IVW method instructed an inverse causative relationship between years of education and RA (β=- 0.039, SE=0.283, p=0.008). MR-Egger regression test showed that directional pleiotropy seems not to bias the MR results (intercept=0.028; p=0.358). MR-Egger analysis demonstrated no causative relationship between RA and years of education (β=- 2.320, SE=1.709, p=0.181). However, the weighted median approach indicated a causative association between RA and years of education (β=-0.950, SE=0.355, p=0.008).<bold>Conclusions: </bold>The MR analysis supported a potential inverse causative relationship between years of education and development of RA.
- Subjects
RHEUMATOID arthritis; SINGLE nucleotide polymorphisms; EDUCATIONAL attainment
- Publication
Postgraduate Medical Journal, 2019, Vol 95, Issue 1125, p378
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2018-136374