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- Title
Invasive Aspergillosis in Liver Transplant Recipients: Association with Candidemia and Consumption Coagulopathy and Failure of Prophylaxis with Low-Dose Amphotericin B.
- Authors
Singh, Nina; Mieles, Luis; Yu, Victor L.; Gayowski, Timothy
- Abstract
Invasive aspergillosis developed in three (5%) of 55 adult liver transplant recipients at our institution. All three of our patients had concomitant candidemia and consumption coagulopathy, and invasive aspergillosis developed while they were receiving therapy with intravenous amphotericin B (0.5 mg/[kg · d]). The simultaneous occurrence of candidemia and invasive aspergillosis in liver transplant recipients may reflect a common defect in the host-defense mechanism against Candida and Aspergillus organisms (i.e., impaired phagocytic and mononuclear macrophage function) and liver disease per se. These three cases suggest that such low-dose intravenous amphotericin B will likely be ineffective if used as antifungal prophylaxis for invasive aspergillosis.
- Publication
Clinical Infectious Diseases, 1993, Vol 17, Issue 5, p906
- ISSN
1058-4838
- Publication type
Article