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- Title
Graphene Oxide-Based Nanocomposites Decorated with Silver Nanoparticles as an Antibacterial Agent.
- Authors
Jaworski, Sławomir; Wierzbicki, Mateusz; Sawosz, Ewa; Jung, Anna; Gielerak, Grzegorz; Biernat, Joanna; Jaremek, Henryk; Łojkowski, Witold; Woźniak, Bartosz; Wojnarowicz, Jacek; Stobiński, Leszek; Małolepszy, Artur; Mazurkiewicz-Pawlicka, Marta; Łojkowski, Maciej; Kurantowicz, Natalia; Chwalibog, André
- Abstract
One of the most promising methods against drug-resistant bacteria can be surface-modified materials with biocidal nanoparticles and nanocomposites. Herein, we present a nanocomposite with silver nanoparticles (Ag-NPs) on the surface of graphene oxide (GO) as a novel multifunctional antibacterial and antifungal material. Ultrasonic technologies have been used as an effective method of coating polyurethane foils. Toxicity on gram-negative bacteria (<italic>Escherichia coli</italic>), gram-positive bacteria (<italic>Staphylococcus aureus</italic> and <italic>Staphylococcus epidermidis</italic>), and pathogenic yeast (<italic>Candida albicans</italic>) was evaluated by analysis of cell morphology, assessment of cell viability using the PrestoBlue assay, analysis of cell membrane integrity using the lactate dehydrogenase assay, and reactive oxygen species production. Compared to Ag-NPs and GO, which have been widely used as antibacterial agents, our nanocomposite shows much higher antimicrobial efficiency toward bacteria and yeast cells.
- Subjects
NANOCOMPOSITE materials; GRAPHENE oxide; SILVER nanoparticles; ANTIBACTERIAL agents; BACTERIA; GRAM-negative bacteria
- Publication
Nanoscale Research Letters, 2018, Vol 13, Issue 1, p1
- ISSN
1931-7573
- Publication type
Article
- DOI
10.1186/s11671-018-2533-2