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- Title
Involvement of Interferon‐γ + 874A/T Polymorphism in the Pathogenesis of and Therapeutic Response to Immune Thrombocytopenia.
- Authors
Rezaeeyan, Hadi; Jaseb, Kaveh; Kaydani, Gholam Abas; Asnafi, Ali Amin; Masbi, Mohammad Hosein; Saki, Najmaldin
- Abstract
Background Immune thrombocytopenia (ITP) is an autoimmune disease characterized by symptoms of thrombocytopenia and bleeding due to production of autoantibodies against platelets. Recently, the occurrence of polymorphisms has been identified as one of the main causes of disease onset. Methods To conduct this study, we recruited 140 patients and control individuals with no history of platelet loss. After collection of specimens, the prevalence of interferon-γ polymorphism was evaluated using the allele-specific oligonucleotide–polymerase chain reaction (ASO-PCR) technique and confirmed by sequencing techniques. Results The results showed that the frequency of the AA genotype was higher in the control group, compared with patients with ITP; however, in the acute and chronic groups, the frequency of the AT genotype was higher than that of the AA genotype. We also discovered that there was no significant correlation between platelet counts before and after treatment, nor in its related parameters with interferon (IFN)–γ polymorphism. Conclusion rs2430561 does not seem to have any role in ITP pathogenesis and treatment response.
- Subjects
IRAN; AGE factors in disease; GENETIC polymorphisms; INTERFERONS; POLYMERASE chain reaction; REGRESSION analysis; RESEARCH funding; T-test (Statistics); THROMBOPENIC purpura; DISEASE prevalence; DATA analysis software; OLIGONUCLEOTIDE arrays; PLATELET count; MANN Whitney U Test; GENOTYPES
- Publication
Laboratory Medicine, 2019, Vol 50, Issue 3, pe42
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmz010