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- Title
Catalytic Asymmetric Hydrogenation of α-CF<sub>3</sub>- or β-CF<sub>3</sub>-Substituted Acrylic Acids using Rhodium(I) Complexes with a Combination of Chiral and Achiral Ligands.
- Authors
Dong, Kaiwu; Li, Yang; Wang, Zheng; Ding, Kuiling
- Abstract
Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92–>99 %).
- Subjects
RHODIUM catalysts; CATALYTIC hydrogenation; ADDITION reactions; LIGANDS (Chemistry); PLATINUM group catalysts; CHEMICAL reactions
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 52, p14191
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201307903