We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-Term Outcomes of Prostaglandin Analog Versus Timolol Maleate in Ocular Hypertensive or Primary Open-Angle Glaucoma Patients in Europe.
- Authors
Holló, Gábor; Thelen, Ulrich; Teus, Miguel A.; Quaranta, Luciano; Ferkova, Sylvia; Babić, Nikola; Misiuk-Hojlo, Marta; Mikropoulos, Dimitrios G.; Kaluzny, Bartlomiej J.; Kozobolis, Vassilios; Januleviciene, Ingrida; Kóthy, Péter; Camara, Cristina; Russo, Andrea; Krzyzanowska-Berkowska, Patrycja; Cieślińska, Iwona; Stewart, Jeanette A.; Kristoffersen, Michael S.; Nelson, Lindsay A.; Stewart, William C.
- Abstract
Purpose: To determine the direct costs of therapy over 5 years of a European monotherapy cohort begun on a prostaglandin (PTG) versus timolol in patients with primary open-angle glaucoma or ocular hypertension. Methods: A retrospective, multicenter, active-controlled, observational study. Data were abstracted for European patients treated as initial monotherapy in 1996 or afterward, with 5 years of available records. Results: This study included 271 patients (166 on a PTG and 105 on timolol at baseline). The average cost/month/patient over 5 years was $45.47±12.61 for PTG and $31.50±15.47 for timolol ( P<0.001, based on German prices). After 5 years, although there was no difference in number of glaucoma medicines prescribed between groups (1.0 PTGs and 1.1 timolol, P=0.41), the timolol group demonstrated a higher intraocular pressure (17.7±2.9 vs. 16.5±3.0 mm Hg, P<0.001), more medication changes ( P=0.01), greater incidence of glaucomatous progression ( P=0.04), and less patients persistent on original monotherapy ( P<0.001) than the PTG cohort. Conclusions: Patients originally on timolol monotherapy have a lower cost of care over 5 years than those started on a PTG. However, timolol patients during follow-up may demonstrate a higher intraocular pressure, more progression, more medication changes, and lower persistency of the original monotherapy.
- Subjects
EUROPE; INTRAOCULAR pressure; PROSTAGLANDINS; TIMOLOL maleate; OPEN-angle glaucoma; FOLLOW-up studies (Medicine); EYE diseases; PATIENTS
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2011, Vol 27, Issue 5, p493
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2011.0051