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- Title
Risk factors for incidence and case-fatality rates of healthcare-associated infections: a 20-year follow-up of a hospital-based cohort.
- Authors
WANG, R.-F.; SHEN, S.-H.; YEN, A. M.-F.; WANG, T.-L.; JANG, T.-N.; LEE, S.-H.; WANG, J.-T.; CHEN, H.-H.
- Abstract
Information is lacking on the integrated evaluation of mortality rates in healthcare-associated infections (HAIs). Our aim was to differentiate the risk factors responsible for the incidence from those for the case-fatality rates in association with HAIs. We therefore examined the time trends of both incidence and case-fatality rates over a 20-year period at a tertiary-care teaching medical centre in Taiwan and the mortality rate was expressed as the product of the incidence rate and the case-fatality rate. During the study period the overall mortality rate fell from 0·46 to 0·32 deaths/1000 patient-days and the incidence rate fell from 3·41 to 2·31/1000 patient-days, but the case-fatality rate increased marginally from 13·5% to 14·0%. The independent risk factors associated with incidence of HAIs were age, gender, infection site, admission type, and department of hospitalization. Significant prognostic factors for HAI case-fatality were age, infection site, intensive care, and clinical department. We conclude that the decreasing trend for the HAI mortality rate was accompanied by a significant decline in the incidence rate and this was offset by a slightly increasing trend in the case-fatality rate. This deconstruction approach could provide further insights into the underlying complex causes of mortality for HAIs.
- Subjects
TAIWAN; MEDICAL care; COHORT analysis; TERTIARY care; MEDICAL centers; HOSPITAL care; CROSS infection; LONGITUDINAL method; DISEASE incidence
- Publication
Epidemiology & Infection, 2016, Vol 144, Issue 1, p198
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/S0950268815000369