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- Title
PROGNOSTIC SIGNIFICANCE OF BCL-6 PROTEIN AND KI-67 MONOCLONAL ANTIBODY IN LARGE CELL B-LYMPHOMA TREATED WITH POLICHEMIOTHERAPY WITH OR WITHOUT ADDITION OF RITUXIMAB.
- Authors
Arnautovic-Custovic, Aida; Cičkusic, Elmir; Hasic, Samira; Sahovic, Haris; Jovanovic, Predrag; Jovic, Svetlana
- Abstract
Introduction: Diffuse large cell lymphoma (DLCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for almost 35-40% of all cases of NHL. Aim: To analyse the expression of Ki-67 i bcl-6 in large cell lymphoma tissue, treated with CHOP and CHOP+R protocol, and to evaluate the level of therapeutic response and the duration of progression free survival in patients treated by therapeutic protocols CHOP and CHOP+R. Methods: For analysis of both Ki-67 and bcl-6 we used criterion for positivity of more than 10% protein expression in lymphoid tissue. Results: In total sample there was 48.3% bcl-6 positive cells. Comparing two different treatments, there was no difference in level of bcl-6 expression. (Mann-Whitney; U=398; p=0.44). No significant difference was found in incidence of bcl-6 positive patients between two types of treatment (X²=0.60; df=1; p=0.44). All the patients were Ki-67 positive. Compared within two therapeutic groups, there was no difference in level of Ki-67 expression (Mann-Whitney; U=403.5; p=0.49). In the group of patients treated with CHOP protocol niether bcl-6 nor Ki-67 showed influence on duration of progression free survival. In the group of patients treated with CHOP+R protocol, there was also no influence of bcl-6 and Ki-67 on duration of progression free survival. Conclusions: Results suggest that Ki-67 and bcl-6 expression in tumor tissue can not be used as indicators for the level of therapy response and progression-free survival in DLCL treated with polichemiotherapy with or without addition of Rituximab.
- Subjects
BCL-6 protein; MONOCLONAL antibodies; LYMPHOMAS; RITUXIMAB; GENE expression; COMPARATIVE studies
- Publication
Acta Medica Saliniana, 2012, Vol 41, Issue 1, p6
- ISSN
0350-364X
- Publication type
Article
- DOI
10.5457/ams.165.10